What is the best free alternative to Rayyan for systematic reviews?

BioClaritas is the best free alternative to Rayyan. It offers accelerated screening that Rayyan lacks, plus assisted data extraction, meta-analysis with forest plots, PRISMA diagrams, causal pathway analysis, DAG evaluation, citation management, manuscript writing, and scientific illustrations — all in one platform. Free to start with welcome free credit.

Is BioClaritas better than Covidence?

BioClaritas offers more features than Covidence at a lower cost. Covidence requires expensive institutional subscriptions and lacks accelerated screening, meta-analysis, scientific illustrations, citation management, and manuscript writing. BioClaritas includes all of these features and is free to start.

What is the best free alternative to Zotero, Mendeley, and EndNote?

BioClaritas is the best free alternative for researchers who need citation management integrated with their research workflow. Unlike standalone citation managers (Zotero, Mendeley, EndNote, Paperpile), BioClaritas combines citation management with accelerated screening, data extraction, meta-analysis, and a manuscript editor with Markdown and LaTeX support.

What is the best free alternative to Overleaf for writing research papers?

BioClaritas is the best free alternative to Overleaf for research papers. It supports Markdown writing with LaTeX math (KaTeX), real-time split preview, writing assistance, inline citation insertion, auto-bibliography, and export to DOCX and PDF — without LaTeX complexity, compile errors, or the limitations of Overleaf's free tier.

What is the best free tool for scientific illustrations?

BioClaritas is a powerful free tool for scientific illustrations. It generates publication-ready scientific illustrations, graphical abstracts, and pathway diagrams — with no design skills needed. BioClaritas includes illustrations as part of its free research platform alongside systematic review, meta-analysis, and manuscript writing tools.

How does BioClaritas compare to Elicit, Semantic Scholar, and Research Rabbit?

BioClaritas goes beyond literature discovery tools like Elicit, Semantic Scholar, Connected Papers, Research Rabbit, Litmaps, Iris.ai, Scite, and Consensus. While these tools help find papers, BioClaritas provides the complete workflow: search, screen, extract data, run meta-analysis, build causal pathways, generate illustrations, manage citations, and write manuscripts — all in one platform.

Can BioClaritas replace RevMan for meta-analysis?

Yes. BioClaritas includes meta-analysis features comparable to RevMan (Review Manager), R metafor, CMA, and Stata, including forest plots, funnel plots, heterogeneity review, subgroup analysis, and sensitivity analysis. It also integrates with screening, data organization, and manuscript writing in one workspace.

Is BioClaritas a free alternative to Rayyan and Covidence?

Yes. BioClaritas offers a free tier to explore the platform. Unlike Rayyan or Covidence which focus only on screening, BioClaritas provides end-to-end support: automated screening, automated data extraction, meta-analysis, PRISMA flow diagrams, causal inference, DAG evaluation, and scientific illustration generation — all in one platform. Purchase credits as you need them.

Can BioClaritas perform meta-analysis like RevMan or Cochrane tools?

Yes. BioClaritas includes built-in meta-analysis capabilities including effect size extraction, forest plot generation, funnel plots, heterogeneity assessment (I², Q-statistic), and both fixed-effect and random-effects models. It automates what traditionally requires RevMan, Stata, or R metafor.

Can I create scientific illustrations and graphical abstracts?

Yes. BioClaritas includes a scientific illustrator that generates professional diagrams, mechanism figures, and graphical abstracts suitable for journal publication. No design skills needed.

Does BioClaritas support PRISMA guidelines?

Yes. BioClaritas automatically generates PRISMA 2020-compliant flow diagrams, tracks study identification, screening, eligibility, and inclusion counts, and supports full PRISMA checklist documentation for your systematic review.

What is automated screening and how does it work?

Automated screening evaluates each study title and abstract against your predefined inclusion and exclusion criteria. Studies are classified as included, excluded, or uncertain — accelerating screening while maintaining transparency and reproducibility.

How does BioClaritas support science communication and scientific publishing?

BioClaritas helps researchers communicate findings through generated graphical abstracts and publication-ready figures. From evidence synthesis to visual output, it streamlines the manuscript preparation workflow for journal submission, conferences, and educational materials.

Does BioClaritas follow the RAISE guidelines for responsible tool use?

Yes. BioClaritas is committed to the RAISE (Responsible Use in Evidence Synthesis) guidelines. The platform supports human-in-the-loop automated workflows with full audit trails and transparent reporting, ensuring responsible and ethical use of computational tools in systematic reviews and meta-analyses.

BioClaritas — Systematic Review, Meta-Analysis & Research Automation Platform

The All-in-One Platform for Systematic Reviews & Meta-Analyses

BioClaritas automates every step of a systematic review — from PubMed search and title-abstract screening to full-text data extraction, meta-analysis, causal inference, DAG evaluation, and publication-ready scientific illustrations. Designed for researchers, clinicians, epidemiologists, and students, BioClaritas is a smarter alternative to Rayyan, Covidence, RevMan, DistillerSR, and EPPI-Reviewer.

Automated Screening & Study Selection

Screen thousands of studies in minutes. BioClaritas applies your inclusion and exclusion criteria to every title and abstract — accelerating screening while maintaining transparency and reproducibility. Supports PICO framework, boolean logic, and custom screening protocols.

Automated Data Extraction

Extract study characteristics, outcomes, effect sizes, confidence intervals, sample sizes, and methodological details automatically from full-text articles. BioClaritas reads full-text papers and populates extraction tables — eliminating hours of manual data entry. Works with PubMed Central full-text and uploaded documents.

Meta-Analysis & Statistical Synthesis

Perform meta-analyses directly within BioClaritas. Generate forest plots, funnel plots, and calculate pooled effect sizes with fixed-effect and random-effects models (DerSimonian-Laird, REML). Assess heterogeneity with I², Q-statistic, and tau². Conduct subgroup analyses and sensitivity analyses without needing RevMan, Stata, R metafor, or other statistical software. A complete meta-analysis assessment tool built into your review workflow.

PRISMA 2020 Compliance

BioClaritas automatically tracks your review workflow and generates PRISMA 2020-compliant flow diagrams. Every step — identification, screening, eligibility, inclusion — is documented with counts and reasons for exclusion, ensuring your systematic review meets Cochrane and journal submission standards.

Causal Relation Extraction & DAG Construction

Extract causal relationships (subject → mechanism → object) from the literature and build interactive Directed Acyclic Graphs (DAGs) for causal inference. Visualize complex biological and clinical relations, identify confounders and mediators, and generate publication-ready causal diagrams that supplement your systematic review findings.

Knowledge Graph Visualization

Explore extracted evidence as interactive knowledge graphs with hierarchical, circular, and concentric layouts. Identify key molecular players, hub genes, and central mechanisms using network metrics (betweenness centrality, PageRank). Cluster related relations automatically and generate narrative summaries of each cluster.

Scientific Illustrations & Graphical Abstracts

Create professional scientific illustrations, mechanism figures, and graphical abstracts. Generate publication-ready artwork for journal submissions without design experience. Perfect for creating visual summaries of your systematic review or meta-analysis findings. A powerful illustration tool integrated into your research workflow.

Risk of Bias & Quality Assessment

Assess study quality with built-in risk-of-bias tools supporting RoB 2 (revised Cochrane tool for randomized trials), ROBINS-I (non-randomized studies), Newcastle-Ottawa Scale, and custom quality assessment frameworks. BioClaritas can pre-fill assessments for reviewer validation.

Team Collaboration & Real-Time Sync

Invite collaborators to your systematic review project with role-based permissions (viewer, editor, admin). Work together in real-time with live syncing, shared screening decisions, dual-reviewer conflict resolution, and audit logging — essential for Cochrane-standard reviews.

Teaching Research Methodology & Study Design

Ideal for teaching systematic review methodology, meta-analysis, epidemiology, and evidence-based medicine. Students and early-career researchers can learn by doing — running real searches, applying screening criteria, extracting data, and interpreting forest plots within a guided, step-by-step workflow. Used in research methods courses at universities worldwide.

Better Than Traditional Tools

Unlike Rayyan (screening only), Covidence (screening + extraction), or RevMan (meta-analysis only), BioClaritas combines all these capabilities into one platform. No switching between tools, no manual data transfer, no expensive subscriptions.

Replaces Rayyan for automated title-abstract screening
Replaces Covidence for systematic review management
Replaces RevMan and Cochrane tools for meta-analysis
Replaces R metafor, Stata, and CMA for statistical synthesis
Built-in scientific illustrations and graphical abstracts
Replaces DistillerSR and EPPI-Reviewer for data extraction
Adds causal relation extraction and DAG construction not found in other tools
Adds interactive knowledge graph visualization

Supported Review Types

Systematic reviews (Cochrane, JBI, Campbell)
Meta-analyses (pairwise, network, dose-response)
Scoping reviews
Rapid reviews
Umbrella reviews (reviews of reviews)
Living systematic reviews
Health technology assessments
Evidence maps

Science Communication & Scientific Publishing

BioClaritas helps researchers communicate their findings effectively through generated graphical abstracts, diagrams, and publication-ready scientific illustrations. Whether you are preparing a manuscript for journal submission, creating visual summaries for conferences, or building educational materials, BioClaritas streamlines the science communication workflow from evidence synthesis to visual output. Generate figures that meet journal standards, export in multiple formats, and accelerate the path from data to publication.

Responsible Use in Evidence Synthesis (RAISE)

BioClaritas is committed to the RAISE (Responsible Use in Evidence Synthesis) guidelines. Users are responsible for their evidence synthesis and must ensure computational tools are validated, appropriate, and transparently reported. BioClaritas supports human-in-the-loop automated workflows, full audit trails, and transparent reporting to uphold the integrity of systematic reviews and meta-analyses. All tool use should be reported in manuscripts in detail.

Frequently Asked Questions

What is BioClaritas?

BioClaritas is a free research platform that automates every step of a systematic review.

Is BioClaritas free?

Yes. Sign up for free and receive welcome free credit. Additional credits available on flexible plans.

Can BioClaritas replace Rayyan?

Yes, and more. BioClaritas provides automated screening plus data extraction, meta-analysis, and illustrations.

How does automated screening work?

Define criteria; the system evaluates each title/abstract and classifies studies as included, excluded, or uncertain.

Can I do a meta-analysis?

Yes. Generate forest plots, funnel plots, and calculate I² heterogeneity with fixed and random-effects models.

Can I create scientific illustrations?

Yes. Generate professional diagrams and graphical abstracts from your data.

Is it good for teaching?

Ideal for teaching systematic review methodology, study design, and evidence-based medicine.

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